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Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737 )〕 It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG. Two transcript variants encoding different isoforms have been found for this gene.〔 ==Functions== Main effects of prostaglandin binding to the receptor are: * uterine contraction * bronchoconstriction〔Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234〕 Via activation of this receptor, PGF2-alpha mediates luteolysis,〔 and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.〔(Signal transduction in lower esophageal sphincter circular muscle ) Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.〕 Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Prostaglandin F receptor」の詳細全文を読む スポンサード リンク
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